Pat chicken breasts dry with paper towels. If breasts are uneven in thickness, lightly pound the thicker end to even them out.
Rub chicken with olive oil. In a small bowl, combine garlic powder, onion powder, paprika, salt, pepper, and Italian seasoning if using. Season both sides of the chicken evenly, pressing the rub in.
Preheat air fryer to 375 degrees F for 3 to 5 minutes.
Place chicken in a single layer in the air fryer basket. Cook at 375 degrees F for 8 to 10 minutes. Flip and cook an additional 6 to 8 minutes until cooked through.
Transfer to a cutting board and rest 3 to 5 minutes before slicing.